HegeLab.org

Hedvig Tordai, Ph.D.

Education

  • Postdoctoral fellow under guidance of Prof. László Patthy , HAS BRC Institute of Enzymology, 2000-2003;
  • Ph.D. Program in Structural Biochemistry under guidance of Prof. László Patthy, Eötvös Loránd University, Budapest, Hungary, 1993-1996;
  • Undergraduate program in biology, Eötvös Loránd University, Budapest, Hungary, Msc in Biology, 1985-1990;
  • ELTE Radnóti Miklós grammar school, 1981-1985.

Employment History

  • Membrane Research Group, Hungarian Academy of Sciences and Semmelweis University, 2010-present;
  • Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, group of Prof. László Patthy, 1990-2010.

Participation in research projects

  • Membrane topology of ABCG2 protein;
  • Structure-function studies of extracellular modules;
  • Identification of the collagen-binding site of human MMP2/Gelatinase A;
  • Evolution of protein modules and modular proteins;
  • Biosapiens (FP6 LSHG-CT-2003-503265) project.

Grants

  • Bolyai János Research Grant;
  • OTKA Postdoctoral Research Grant.

Publications

(Please also see here)
  • Nagy A, Hegyi H, Farkas K, Tordai H, Kozma E, Bányai L and Patthy L (2008) Identification and correction of abnormal, incomplete and mispredicted proteins in public databases. BMC Bioinformatics 9, 3531.
  • Nagy A, Hegyi H, Farkas K, Tordai H, Kozma E, Banyai L and Patthy L (2008) Quality control of gene predictions Modern Genome Annotation , 41-54
  • Tordai H, Nagy A, Farkas K, Banyai L and Patthy L (2005) Modules, multidomain proteins and organismic complexity. FEBS J 272, 5064-78
  • Jani M, Tordai H, Trexler M, Banyai L and Patthy L (2005) Hydroxamate-based peptide inhibitors of matrix metalloprotease 2. Biochimie 87, 385-92
  • Gehrmann ML, Douglas JT, Banyai L, Tordai H, Patthy L and Llinas M (2004) Modular autonomy, ligand specificity, and functional cooperativity of the three in-tandem fibronectin type II repeats from human matrix metalloproteinase 2. J Biol Chem 279, 46921-9
  • Tordai H and Patthy L (2004) Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides. FEBS Lett 575, 109-11
  • Briknarová K, Gehrmann M, Banyai L, Tordai H, Patthy L and Llinas M (2001) Gelatin-binding region of human matrix metalloproteinase-2: solution structure, dynamics, and function of the COL-23 two-domain construct. J Biol Chem 276, 27613-21
  • Briknarova K, Grishaev A, Banyai L, Tordai H, Patthy L and Llinas M (1999) The second type II module from human matrix metalloproteinase 2: structure, function and dynamics. Structure 7, 1235-45
  • Tordai H, Banyai L and Patthy L (1999) The PAN module: the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein family and with a novel domain found in numerous nematode proteins. FEBS Lett 461, 63-7
  • Tordai H and Patthy L (1999) The gelatin-binding site of the second type-II domain of gelatinase A/MMP-2. Eur J Biochem 259, 513-8
  • Banyai L, Tordai H and Patthy L (1996) Structure and domain-domain interactions of the gelatin binding site of human 72-kilodalton type IV collagenase (gelatinase A, matrix metalloproteinase 2). J Biol Chem 271, 12003-8
  • Banyai L, Tordai H and Patthy L (1994) The gelatin-binding site of human 72 kDa type IV collagenase (gelatinase A). Biochem J 298 (Pt 2), 403-7